![]() The remaining (non-TARGET) data have been deposited in the European Genome Phenome Archive, accession nos. phs000218 (TARGET) and at NCI’s Genomic Data Commons ( ) under project TARGET. TARGET BAM and FASTQ sequence files are accessible through the database of genotypes and phenotypes (dbGaP ) under accession no. TARGET ALL data may be accessed through the TARGET website at. Genomic data are publicly available, and data accessions for RNA-seq, WES, WGS and SNP are listed for each case in Supplementary Table 1. Together, these results deepen understanding of the ALL genomic landscape and associated outcomes. Intriguingly, DUX4- and KMT2A-rearranged subtypes separate into CEBPA/FLT3- or NFATC4-expressing subgroups with potential clinical implications. We also demonstrate the prognostic significance of genetic alterations within subtypes. By contrast, ultraviolet-induced mutations precede chromosomal gains in B-ALL cases with intrachromosomal amplification of chromosome 21. ![]() In hyperdiploid B-ALL, chromosomal gains are acquired early and synchronously before ultraviolet-induced mutation. Most samples harbor at least one rare gene alteration, including 70 putative cancer driver genes associated with ubiquitination, SUMOylation, noncoding transcripts and other functions. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low mutation burden, ALL cases harbor a median of four putative somatic driver alterations per sample, with 376 putative driver genes identified varying in prevalence across ALL subtypes. Nature Genetics volume 54, pages 1376–1389 ( 2022) Cite this articleĪcute lymphoblastic leukemia (ALL) is the most common childhood cancer. The Journal of Abnormal and Social Psychology, 1961 63(3), 575–582 doi:10.The genomic landscape of pediatric acute lymphoblastic leukemia Transmission of aggression through imitation of aggressive models. Cannabis exposure during critical windows of development: epigenetic and molecular pathways implicated in neuropsychiatric disease. Smith A, Kaufman F, Sandy MS, Cardenas A. The impact of external factors on the epigenome: in utero and over lifetime. Toraño EG, García MG, Fernández-Morera JL, Niño-García P, Fernández AF. Perceptions of nature, nurture and behaviour. ![]() National Human Genome Research Institute. ![]() Genetic risk, midlife life’s simple 7, and incident dementia in the atherosclerosis risk in communities study. Journal of Personality and Social Psychology. Sixteen going on sixty-six: A longitudinal study of personality stability and change across 50 years. Genetic and environmental continuity in personality development: A meta-analysis. Innatism, concept formation, concept mastery and formal education: innatism, concept formation and formal education. Missing compared to what? Revisiting heritability, genes and culture. doi:10.1111/j.įeldman MW, Ramachandran S. The heritability of personality is not always 50%: gene-environment interactions and correlations between personality and parenting: heritability is not always 50%. Krueger RF, South S, Johnson W, Iacono W. " Major Personality Study Finds That Traits Are Mostly Inherited."īouchard, Jr. Commentary: the birth of the twin study-a commentary on francis galton’s “the history of twins.” International Journal of Epidemiology. ![]()
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